Peptide

Leuphasyl

Acetyl Glutamyl Heptapeptide-1

Also known as: Acetyl Glutamyl Heptapeptide-1

Leuphasyl is a pentapeptide that works through a different mechanism than Argireline, targeting enkephalin receptors rather than SNARE proteins. Often combined with Argireline for a synergistic effect. Clinical evidence is limited to industry-sponsored studies. Penetration to the neuromuscular junction through intact skin remains the primary challenge.

Ingredient Profile

INCI Name
Acetyl Glutamyl Heptapeptide-1
Common Name
Leuphasyl
Category
Peptide
Function
Anti-ageing, expression line reduction
Typical Usage Rate
1–5%
Comedogenic
0/5 — Non-comedogenic

Comedogenicity ratings are based on the rabbit ear assay model. Individual skin responses vary. See our article on comedogenicity ratings for context.

Suitable Skin Types

All skin typesMature

Related Ingredients

Argireline (Acetyl Hexapeptide-3)

Acetyl Hexapeptide-3

Anti-ageing, expression line reduction

Copper Peptide (GHK-Cu)

Copper Tripeptide-1

Anti-ageing, wound healing, collagen stimulation

Matrixyl (Palmitoyl Pentapeptide-4)

Palmitoyl Pentapeptide-4

Anti-ageing, collagen stimulation

SNAP-8

Acetyl Octapeptide-3

Anti-ageing, expression line reduction

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